Four ARF GAPs in Saccharomyces cerevisiae have both overlapping and distinct functions.

doi:10.1002/yea.966

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Article

Four ARF GAPs in Saccharomyces cerevisiae have both overlapping and distinct functions.

Yeast (Chichester, England) - 1 Mar 2003

Zhang Chun-Jiang, Bowzard J Bradford, Anido Aimee, Kahn Richard A

Abstract excerpt

Previous studies in yeast have revealed the presence of four proteins with a conserved, cysteine-rich, ARF GAP domain that share the ability to suppress the conditional growth defect of the arf1-3 mutant. Three of these proteins have been shown previously to be ADP-ribosylation factor (ARF) GTPase-activating proteins (GAPs). We now demonstrate that the fourth also exhibits in vitro ARF GAP activity and correlates...

Topics

ADP-Ribosylation Factors
Blotting, Western
Fungal Proteins
GTPase-Activating Proteins
Gene Expression Regulation, Fungal
Mutation
Saccharomyces cerevisiae
Signal Transduction
Suppression, Genetic

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PMID: 12627398
DOI: 10.1002/yea.966

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