Article
Three-dimensional structure of poliovirus receptor bound to poliovirus.
Proceedings of the National Academy of Sciences of the United States of America - 4 Jan 2000
Belnap D M, McDermott B M, Filman D J, Cheng N, Trus B L, Zuccola H J, Racaniello V R, Hogle J M, Steven A C
Abstract excerpt
Poliovirus initiates infection by binding to its cellular receptor (Pvr). We have studied this interaction by using cryoelectron microscopy to determine the structure, at 21-A resolution, of poliovirus complexed with a soluble form of its receptor (sPvr). This density map aided construction of a homology-based model of sPvr and, in conjunction with the known crystal structure of the virus, allowed delineation of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.