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Article

Developmental progression of immunoglobulin heavy chain diversity in sheep.

Veterinary immunology and immunopathology - 10 Jan 2005

Gontier Etienne, Ayrault Olivier, Godet Isabelle, Nau François, Ladevèze Véronique

Abstract excerpt

In order to assess the respective impacts of combinatorial rearrangement, junctional diversification, somatic hypermutation and gene conversion in the generation of immunoglobulin heavy chain variable regions diversity, the sequences of 42 variable regions from late fetal, newborn and young sheep were determined and compared to those of adult animals. At earlier stages of development, the use of germline...

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Source

Identifiers

PMID: 15626460
DOI: 10.1016/j.vetimm.2004.08.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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