Developmental progression of immunoglobulin heavy chain diversity in sheep.

doi:10.1016/j.vetimm.2004.08.013

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Article

Developmental progression of immunoglobulin heavy chain diversity in sheep.

Veterinary immunology and immunopathology - 10 Jan 2005

Gontier Etienne, Ayrault Olivier, Godet Isabelle, Nau François, Ladevèze Véronique

Abstract excerpt

In order to assess the respective impacts of combinatorial rearrangement, junctional diversification, somatic hypermutation and gene conversion in the generation of immunoglobulin heavy chain variable regions diversity, the sequences of 42 variable regions from late fetal, newborn and young sheep...

Topics

Amino Acid Sequence
Animals
Base Sequence
Complementarity Determining Regions
Gene Rearrangement
Genetic Variation
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Sheep

Source

Open in PubMed

Identifiers

PMID: 15626460
DOI: 10.1016/j.vetimm.2004.08.013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-15626460-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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