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Article

Inhibition of malignant glioma cell growth by a survivin mutant retrovirus.

Human gene therapy - 1 Feb 2005

Temme A, Herzig E, Weigle B, Morgenroth A, Schmitz M, Kiessling A, Rieger M A, Schackert H K, Rieber E P

Abstract excerpt

Glioblastoma multiforme (GBM) is a highly malignant brain tumor that is resistant to conventional radiotherapy and chemotherapy. The median survival time of patients with GBM has remained less than 2 years despite concerted efforts to improve therapy. As a new approach to treat GBM we generated retroviral particles encoding mutant survivin for transduction of glioma cells. We demonstrate here that retroviral...

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Identifiers

PMID: 15761261
DOI: 10.1089/hum.2005.16.209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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