Article
Molecular biology for platelet alloantigen typing.
Transfusion medicine (Oxford, England) - 1 Dec 1992
Williamson L M, Bruce D, Lubenko A, Chana H J, Ouwehand W H
Abstract excerpt
Hitherto, full investigation of patients with alloimmunization to platelet-specific antigens has been difficult due to the limited availability of both typing reagents and panels of typed platelets. Following recent advances in the understanding of the molecular and genetic basis of platelet alloantigens, it is now possible to genotype individuals for the alleles coding for the epitopes of four platelet antigen...
Topics
- Alleles
- Antigens, Human Platelet
- Blood Donors
- Genotype
- Histocompatibility Testing
- Humans
- Isoantigens
- Platelet Membrane Glycoproteins
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
