Article
Leucine33-proline33 substitution in human platelet glycoprotein IIIa determines HLA-DRw52a (Dw24) association of the immune response against HPA-1a (Zwa/PIA1) and HPA-1b (Zwb/PIA2).
Human immunology - 1 Aug 1992
Kuijpers R W, von dem Borne A E, Kiefel V, Eckhardt C M, Waters A H, Zupanska B, Barz D, Taaning E, Termijtelen A, Ouwehand W H
Abstract excerpt
Alloantibody formation against HPA-1a (Zwa/PIA1) has, to date, only been found in HLA-DRw52(a+) (Dw24) individuals. Alloimmunization against the product of the other HPA-1 allele, HPA-1b, is rare. We have been able to evaluate ten cases of HPA-1b alloimmunization in Europe in order to study wheth...
Topics
- Antigens, Human Platelet
- Blood Platelets
- HLA-DR Antigens
- HLA-DR Serological Subtypes
- Histocompatibility Testing
- Humans
- Integrin beta3
- Isoantibodies
- Leucine
- Membrane Glycoproteins
- Phenotype
- Proline