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A novel polymorphism, 70Leu/Phe, disrupts a consensus Leu residue within the leucine-rich repeat sequence of platelet glycoprotein Ibalpha.

Thrombosis and haemostasis - 1 May 2002

Matsubara Yumiko, Murata Mitsuru, Moriki Takanori, Yokoyama Kenji, Watanabe Naohide, Nakajima Hideaki, Handa Makoto, Kawano Koichi, Aoki Nobuo, Yoshino Hideaki, Ikeda Yasuo

Abstract excerpt

Platelet glycoprotein (GP) Ib/IX/V complex mediates high-shear dependent platelet activation through an interaction with the von Willebrand factor (vWF). All four subunits of the complex have a structural motif, the leucine-rich repeat (LRR) sequence, with leucines in conserved positions. Here we report a new polymorphism, Leu/Phe at residue 70 of GPIbalpha, which disrupts the consensus sequence of the LRR in the...

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PMID: 12038791

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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