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Article

Rational reconstruction of the active site of a class mu glutathione S-transferase.

The Journal of biological chemistry - 23 Dec 1994

Shan S, Armstrong R N

Abstract excerpt

Isoenzymes 3-3 and 4-4 of the mu class glutathione S-transferases share 77% sequence identity but have distinctly different catalytic properties. Analysis of the crystal structure of isoenzyme 3-3 in complex with the diastereomeric products of the addition of GSH to phenanthrene 9,10-oxide (Ji, X., Johnson, W. W., Sesay, M. A., Dickert, L., Prasad, S. M., Ammon, H. L., Armstrong, R. N., and Gilliland, G. L....

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PMID: 7798237

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