Contribution of tyrosine 6 to the catalytic mechanism of isoenzyme 3-3 of glutathione S-transferase.

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Article

Contribution of tyrosine 6 to the catalytic mechanism of isoenzyme 3-3 of glutathione S-transferase.

The Journal of biological chemistry - 5 Mar 1992

Liu S, Zhang P, Ji X, Johnson W W, Gilliland G L, Armstrong R N

Abstract excerpt

The role of the hydroxyl group of tyrosine 6 in the catalytic mechanism of isoenzyme 3-3 of rat glutathione S-transferase has been examined by x-ray crystallography and site-specific replacement of the residue with phenylalanine and evaluation of the catalytic properties of the mutant enzyme. Thi...

Topics

Animals
Binding Sites
Butanones
Catalysis
Dinitrochlorobenzene
Electrons
Glutathione Transferase
Hydrogen-Ion Concentration
Isoenzymes
Kinetics
Mutation
Rats
Spectrophotometry, Ultraviolet
Sulfhydryl Compounds
Tyrosine

Source

Open in PubMed

Identifiers

PMID: 1537822

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1537822-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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