Article
Recruitment of CREB binding protein is sufficient for CREB-mediated gene activation.
Molecular and cellular biology - 1 Mar 2000
Cardinaux J R, Notis J C, Zhang Q, Vo N, Craig J C, Fass D M, Brennan R G, Goodman R H
Abstract excerpt
Phosphorylation of the transcription factor CREB leads to the recruitment of the coactivator, CREB binding protein (CBP). Recent studies have suggested that CBP recruitment is not sufficient for CREB function, however. We have identified a conserved protein-protein interaction motif within the CBP-binding domains of CREB and another transcription factor, SREBP (sterol-responsive element binding protein). In...
Topics
- Amino Acid Sequence
- CREB-Binding Protein
- Cyclic AMP Response Element-Binding Protein
- Gene Expression Regulation
- Humans
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Sequence Alignment
- Signal Transduction
- Trans-Activators
- Transcription, Genetic
- Transcriptional Activation