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Article

Proximal cyclic AMP response element is essential for exendin-4 induction of rat EGR-1 gene.

American journal of physiology. Endocrinology and metabolism - 1 Jan 2007

Kang Jung-Hoon, Kim Myung-Jun, Jang Hwa-In, Koh Kyung-Hee, Yum Keun-Sang, Rhie Duck-Joo, Yoon Shin Hee, Hahn Sang June, Kim Myung-Suk, Jo Yang-Hyeok

Abstract excerpt

Glucagon-like peptide-1 and its potent agonist exendin-4 induce several immediate early response genes (IEGs) that code for transcription factors implicated in cell proliferation, differentiation, and apoptosis. We recently observed that early growth response factor-1 (EGR-1), an IEG product, was required for transcriptional activation of Ccnd1 (cyclin D1) gene by exendin-4. Herein, the regulatory mechanism...

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PMID: 16926376
DOI: 10.1152/ajpendo.00181.2006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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