Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex.

doi:10.1016/s0092-8674(94)90542-8

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Article

Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex.

Cell - 9 Sept 1994

Hayles J, Fisher D, Woollard A, Nurse P

Abstract excerpt

We show here that the state of the p34cdc2-p56cdc13 mitotic B cyclin complex determines whether a fission yeast cell undergoes S phase or mitosis. Mutants defective for p56cdc13 reset to G1 and rereplicate their DNA, while cells completely lacking the p34cdc2-p56cdc13 complex undergo multiple rou...

Topics

CDC2 Protein Kinase
Cell Compartmentation
Cyclin B
Cyclins
DNA Replication
G1 Phase
Mitosis
Models, Biological
Mutation
Protein Binding
Recombinant Proteins
S Phase
Schizosaccharomyces
Time Factors

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