Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Breast cancer genes: therapeutic strategies.

Annals of the New York Academy of Sciences - 29 Dec 1997

Holt J T

Abstract excerpt

Although effective treatments for breast cancer predated the identification of causative molecular defects in humans, it is widely hoped that an understanding and/or manipulation of the key genetic events will lead to even more effective therapies or even cures. Powerful methods of positional cloning and gene identification have identified the breast cancer genes, BRCA1 and BRCA2, which together are responsible...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mice
Share to Mutation
Share to Neoplasm Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to RNA, Messenger

Share to Transcription Factors

Share to Cloning, Molecular

Share to Genetic Markers

Share to Breast Neoplasms

Source

Identifiers

PMID: 9616738
DOI: 10.1111/j.1749-6632.1997.tb48590.x

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Breast cancer genes: therapeutic strategies.PMID 9616738Read ↗

BRCA1 at the crossroad of multiple cellular pathways: approaches for therapeutic interventions.Semantic proximity Read ↗

Expression and function of BRCA1 and BRCA2 in familial and sporadic breast cancer.Semantic proximity Read ↗

Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression.Semantic proximity Read ↗

Gene expression profiles of BRCA1-linked, BRCA2-linked, and sporadic ovarian cancers.Semantic proximity Read ↗

Mutations in human breast cancer cells: dominantly-acting oncogenes and tumor suppressor genes suggest strategies for targeted interference.Semantic proximity Read ↗

Familial breast cancer. Approaching the isolation of a susceptibility gene.Semantic proximity Read ↗

The role of the breast cancer susceptibility gene 1 (BRCA1) in sporadic epithelial ovarian cancerSemantic proximity Read ↗

Human BRCA1 gene rescues the embryonic lethality of Brca1 mutant mice.Semantic proximity Read ↗

Treatment of hereditary breast cancer.Semantic proximity Read ↗

Mechanisms of BRCA1 tumor suppression.Semantic proximity Read ↗

Growth retardation and tumour inhibition by BRCA1.Semantic proximity Read ↗

Preferential allelic expression can lead to reduced expression of BRCA1 in sporadic breast cancers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.