Article
Mechanism of tonB-dependent transport of KP-736, a 1,5-dihydroxy-4-pyridone-substituted cephalosporin, into Escherichia coli K-12 cells.
Antimicrobial agents and chemotherapy - 1 Mar 1995
Tatsumi Y, Maejima T, Mitsuhashi S
Abstract excerpt
The mechanism of transport of KP-736, a novel cephalosporin with a 1,5-dihydroxy-4-pyridone moiety at the C-7 position, into the Escherichia coli K-12 cell was investigated by determining the susceptibilities of iron transport mutants to KP-736. The tonB mutant showed a higher degree of resistance to KP-736, indicating that KP-736 was incorporated into E. coli cells via the tonB-dependent iron transport system....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.