Article
Mechanism of tonB-dependent transport of KP-736, a 1,5-dihydroxy-4-pyridone-substituted cephalosporin, into Escherichia coli K-12 cells.
Antimicrobial agents and chemotherapy - 1 Mar 1995
Tatsumi Y, Maejima T, Mitsuhashi S
Abstract excerpt
The mechanism of transport of KP-736, a novel cephalosporin with a 1,5-dihydroxy-4-pyridone moiety at the C-7 position, into the Escherichia coli K-12 cell was investigated by determining the susceptibilities of iron transport mutants to KP-736. The tonB mutant showed a higher degree of resistanc...
Topics
- Bacterial Outer Membrane Proteins
- Bacterial Proteins
- Biological Transport
- Cephalosporins
- Electrophoresis, Polyacrylamide Gel
- Escherichia coli
- Escherichia coli Proteins
- Iron
- Membrane Proteins
- Microbial Sensitivity Tests
- Mutation
- Porins
- beta-Lactamases