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Mechanism of action of cefiderocol

4 Oct 2022

Abstract excerpt

Gram-negative bacilli are intrinsically resistant to many antibiotics due to the low permeability of their outer membrane. The most effective strategy to solve this problem has been the design of antibiotics that cross the membrane using specific transport systems. This is the case of cefiderocol, which, unlike cefepime or ceftazidime, has a chlorocatechol group at the end of the C-3 side chain. This group is...

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PMID: 36193980
DOI: 10.37201/req/s02.02.2022

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