Article
Interleukin-6-dependent gene expression profiles in multiple myeloma INA-6 cells reveal a Bcl-2 family-independent survival pathway closely associated with Stat3 activation.
Blood - 1 Jan 2004
Brocke-Heidrich Katja, Kretzschmar Antje K, Pfeifer Gabriele, Henze Christian, Löffler Dennis, Koczan Dirk, Thiesen Hans-Jürgen, Burger Renate, Gramatzki Martin, Horn Friedemann
Abstract excerpt
Interleukin 6 (IL-6) is a growth and survival factor for multiple myeloma cells. As we report here, the IL-6-dependent human myeloma cell line INA-6 responds with a remarkably rapid and complete apoptosis to cytokine withdrawal. Among the antiapoptotic members of the B-cell lymphoma-2 (Bcl-2) family of apoptosis regulators, only myeloid cell factor-1 (Mcl-1) was slightly induced by IL-6. Overexpression studies...
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