Article
Interleukin-6 Prevents the Initiation but Enhances the Progression of Lung Cancer.
Cancer research - 15 Aug 2015
Qu Zhaoxia, Sun Fan, Zhou Jingjiao, Li Liwen, Shapiro Steven D, Xiao Gutian
Abstract excerpt
Recent studies suggest that high expression of the proinflammatory cytokine IL6 is associated with poor survival of lung cancer patients. Accordingly, IL6 has been a target of great interest for lung cancer therapy. However, the role of IL6 in lung cancer has not been determined yet. Here, we demonstrate that IL6 plays opposite roles in the initiation and growth of lung cancer in a mouse model of lung cancer...
Topics
- Animals
- CD8-Positive T-Lymphocytes
- Cell Proliferation
- Chemokines
- Cyclin D1
- Disease Progression
- Gene Expression
- Homeostasis
- Immunohistochemistry
- Interleukin-10
- Interleukin-6
- Lung
- Lung Neoplasms
- Macrophages