Article
HIV type 1 V3 variation dynamics in vivo: long-term persistence of non-syncytium-inducing genotypes and transient presence of syncytium-inducing genotypes during the course of progressive AIDS.
AIDS research and human retroviruses - 10 Dec 1997
Ida S, Gatanaga H, Shioda T, Nagai Y, Kobayashi N, Shimada K, Kimura S, Iwamoto A, Oka S
Abstract excerpt
We performed a population-based sequence analysis of the envelope V3 region of human immunodeficiency virus type 1 (HIV-1) in two infected hemophiliacs. The study was conducted over 6-9 years, extending from the asymptomatic phase to AIDS. In both patients, serial analysis showed that the V3 popu...
Topics
- Acquired Immunodeficiency Syndrome
- Amino Acid Sequence
- Disease Progression
- Evolution, Molecular
- Genetic Variation
- Genotype
- Giant Cells
- HIV Envelope Protein gp120
- HIV-1
- Humans
- Molecular Sequence Data
- Multigene Family
- Peptide Fragments