Article
Insulin and islet cell autoantibodies as time-dependent covariates in the development of insulin-dependent diabetes: a prospective study in relatives.
The Journal of clinical endocrinology and metabolism - 1 Sept 1993
Krischer J P, Schatz D, Riley W J, Spillar R P, Silverstein J H, Schwartz S, Malone J, Shah S, Vadheim C M, Rotter J I
Abstract excerpt
Using time-dependent methods, the temporal relationships between the detection of insulin and islet cell autoantibodies and the onset of insulin dependent diabetes (IDDM) were analyzed in a prospective study of 4694 nondiabetic relatives of 1929 patients with IDDM who had been followed for a median of 4 yr. Insulin autoantibodies were detected in 1.5% of relatives at their initial test whereas an additional 1.0%...
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