Article
Sequence analysis of the diabetes-protective human leukocyte antigen-DQB1*0602 allele in unaffected, islet cell antibody-positive first degree relatives and in rare patients with type 1 diabetes.
The Journal of clinical endocrinology and metabolism - 1 May 1999
Pugliese A, Kawasaki E, Zeller M, Yu L, Babu S, Solimena M, Moraes C T, Pietropaolo M, Friday R P, Trucco M, Ricordi C, Allen M, Noble J A, Erlich H A, Eisenbarth G S
Abstract excerpt
The human leukocyte antigen (HLA)-DQA1*0102/DQB1*0602/DRB1*1501 (DR2) haplotype confers strong protection from type 1 diabetes. Growing evidence suggests that such protection may be mostly encoded by the DQB1*0602 allele, and we reported that even first degree relatives with islet cell antibodies (ICA) have an extremely low diabetes risk if they carry DQB1*0602. Recently, novel variants of the DQB1*0602 and *0603...
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