Article
ICA+ relatives with DQA1*0102/DQB1*0602 have expected 0602 sequence and DR types.
Journal of autoimmunity - 1 Feb 2002
Greenbaum Carla J, Gaur Lakshmi K, Noble Janelle A
Abstract excerpt
The HLA haplotype DQA1*0102/DQB1*0602 reportely confers protection from type 1 diabetes. DQA1*0102/DQB1*0602 is present in more than 7% of ICA positive relatives screened as part of the Diabetes Prevention Trial--type 1. The presence of autoantibodies in these subjects suggests that the mechanism that protects DQB1*0602 subjects from diabetes occurs after the disease process has been initiated. However, as...
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