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Article

E2F1 in gliomas: a paradigm of oncogene addiction.

Cancer letters - 18 May 2008

Alonso Marta M, Alemany Ramon, Fueyo Juan, Gomez-Manzano Candelaria

Abstract excerpt

Cancer arises as a result of a stepwise accumulation of genetic changes. One of these changes, deregulation of the Rb/E2F1 pathway resulting from alterations in members of the pathway, is a hallmark of all human cancers. These mutations promote tumor development by deregulating the E2F family of transcription factors, which results in uncontrolled cell cycle progression. The E2F1 protein functions as a...

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Identifiers

PMID: 18334281
DOI: 10.1016/j.canlet.2008.02.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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