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Article

E2F1 in gliomas: a paradigm of oncogene addiction.

Cancer letters - 18 May 2008

Alonso Marta M, Alemany Ramon, Fueyo Juan, Gomez-Manzano Candelaria

Abstract excerpt

Cancer arises as a result of a stepwise accumulation of genetic changes. One of these changes, deregulation of the Rb/E2F1 pathway resulting from alterations in members of the pathway, is a hallmark of all human cancers. These mutations promote tumor development by deregulating the E2F family of...

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PMID: 18334281
DOI: 10.1016/j.canlet.2008.02.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18334281-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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