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Article

Efficient test for deviation from Hardy-Weinberg equilibrium with known or ambiguous typing in highly polymorphic loci.

Briefings in bioinformatics - 25 Jul 2024

Shkuri Or, Israeli Sapir, Tshuva Yuli, Maiers Martin, Louzoun Yoram

Abstract excerpt

The Hardy-Weinberg equilibrium (HWE) assumption is essential to many population genetics models. Multiple tests were developed to test its applicability in observed genotypes. Current methods are divided into exact tests applicable to small populations and a small number of alleles, and approximate goodness-of-fit tests. Existing tests cannot handle ambiguous typing in multi-allelic loci. We here present a novel...

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Identifiers

PMID: 39302340
DOI: 10.1093/bib/bbae416
PMCID: PMC11414081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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