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Article

Segregation distortion: Utilizing simulated genotyping data to evaluate statistical methods.

PloS one - 1 Jan 2020

Coulton Alexander, Przewieslik-Allen Alexandra M, Burridge Amanda J, Shaw Daniel S, Edwards Keith J, Barker Gary L A

Abstract excerpt

Segregation distortion is the phenomenon in which genotypes deviate from expected Mendelian ratios in the progeny of a cross between two varieties or species. There is not currently a widely used consensus for the appropriate statistical test, or more specifically the multiple testing correction procedure, used to detect segregation distortion for high-density single-nucleotide polymorphism (SNP) data. Here we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32074141
DOI: 10.1371/journal.pone.0228951
PMCID: PMC7029859

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