Tests of random mating for a highly polymorphic locus: application to HLA data.

Article

Tests of random mating for a highly polymorphic locus: application to HLA data.

Biometrics - 1 Sept 1995

Jin K, Speed T P, Thomson G

Abstract excerpt

Testing for random mating at an HLA locus is a difficult problem because of the highly polymorphic nature of the HLA loci. We discuss some methodological issues and propose several tests. A simulation study is conducted to evaluate these tests. The single allele test and the shared allele test de...

Topics

Alleles
Biometry
Crosses, Genetic
Family
Female
Genotype
HLA-A Antigens
HLA-B Antigens
HLA-DR Antigens
Humans
Major Histocompatibility Complex
Male
Mathematics
Models, Genetic
Models, Statistical
Polymorphism, Genetic
Random Allocation
White People

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.