Article
Aggression modulates genetic influences on morphine analgesia as assessed using a classical mendelian cross analysis.
Psychopharmacology - 1 Jan 1993
Miner L L, Elmer G I, Pieper J O, Marley R J
Abstract excerpt
Pharmacogenetic techniques allow for the examination of genetic and environmental factors underlying phenotypes associated with drug response. Initial studies of mice bred at Jackson Laboratories (JAX) indicated that C57BL/6J mice were more sensitive to morphine-induced analgesia, as measured by latency to paw lick, than SJL/J mice. A classical Mendelian cross breeding program was initiated in which F1, F2 and...
Topics
- Aggression
- Analgesia
- Animals
- Crosses, Genetic
- Dose-Response Relationship, Drug
- Environment
- Mice
- Mice, Inbred C57BL
- Mice, Inbred Strains
- Morphine
- Pain Measurement