Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oligogenic determination of morphine analgesic magnitude: a genetic analysis of selectively bred mouse lines.

Behavior genetics - 1 Jul 1995

Mogil J S, Flodman P, Spence M A, Sternberg W F, Kest B, Sadowski B, Liebeskind J C, Belknap J K

Abstract excerpt

Two ongoing selective breeding projects have produced mice that display divergent analgesic responses to morphine. These two projects have selected for similar phenotypes: high and low levorphanol analgesia (HAR/LAR lines; Portland, OR) and high and low swim stress-induced analgesia (HA/LA lines; Jastrzebiec, Poland). Evidence suggests genetic commonalities between mice of the two projects. Using a Mendelian...

Topics

Analgesics, Opioid
Animals
Crosses, Genetic
Female
Genetic Complementation Test
Levorphanol
Male
Mice
Mice, Inbred Strains
Pain Threshold
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Selection, Genetic

Thermosensing

Source

Identifiers

PMID: 7575370
DOI: 10.1007/BF02197290

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7575370-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oligogenic determination of morphine analgesic magnitude: a genetic analysis of selectively bred mouse lines.PMID 7575370Read ↗

One or two genetic loci mediate high opiate analgesia in selectively bred mice.Semantic proximity Read ↗

Differential genetic mediation of sensitivity to morphine in genetic models of opiate antinociception: influence of nociceptive assay.Semantic proximity Read ↗

Mu and delta opioid receptor analgesia, binding density, and mRNA levels in mice selectively bred for high and low analgesia.Semantic proximity Read ↗

Pain, analgesia and genetics.Semantic proximity Read ↗

Quantitative trait loci influencing morphine antinociception in four mapping populations.Semantic proximity Read ↗

Association of morphine-induced antinociception with variations in the 5' flanking and 3' untranslated regions of the mu opioid receptor gene in 10 inbred mouse strains.Semantic proximity Read ↗

Mice congenic for a locus that determines phenotype in the neuroma model of neuropathic pain.Semantic proximity Read ↗

Genetic variation in morphine analgesic tolerance: a survey of 11 inbred mouse strains.Semantic proximity Read ↗

Heritability of symptoms in the neuroma model of neuropathic pain: replication and complementation analysis.Semantic proximity Read ↗

The heritability of oxycodone reward and concomitant phenotypes in a LG/J × SM/J mouse advanced intercross line.Semantic proximity Read ↗

Association between the A107V substitution in the δ-opioid receptors and ethanol drinking in mice selected for high and low analgesia.Semantic proximity Read ↗

The genetic mediation of individual differences in sensitivity to pain and its inhibitionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.