Mu and delta opioid receptor analgesia, binding density, and mRNA levels in mice selectively bred for high and low analgesia.

doi:10.1016/s0006-8993(98)01141-x

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Article

Mu and delta opioid receptor analgesia, binding density, and mRNA levels in mice selectively bred for high and low analgesia.

Brain research - 23 Jan 1999

Kest B, Jenab S, Brodsky M, Sadowski B, Belknap J K, Mogil J S, Inturrisi C E

Abstract excerpt

The present study examined mu and delta opioid analgesia, receptor binding, and receptor mRNA levels in lines of mice from two selective breeding projects of relevance to opioid analgesia. Large differences were observed in the analgesic potency of [d-Ala2, NMPhe4, Gly-ol]enkephalin (DAMGO), [d-P...

Topics

Analgesics, Opioid
Animals
Dose-Response Relationship, Drug
Female
Male
Mice
Phenotype
RNA, Messenger
Receptors, Opioid, delta
Receptors, Opioid, mu

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