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Article

Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site.

Biological & pharmaceutical bulletin - 1 Jun 2002

Kashiwakura Jun-Ichi, Suzuki Noboru, Takeno Mitsuhiro, Itoh Saotomo, Oku Teruaki, Sakane Tsuyoshi, Nakajin Shizuo, Toyoshima Satoshi

Abstract excerpt

We have previously shown that Txk, a member of Tec family tyrosine kinase, is expressed in Th1 and ThO cells and directly contributes to gene transcription of Th1-related proteins, including interferon (IFN)-gamma, through nuclear translocation in response to mitogenic stimuli. Btk, another member of Tec family tyrosine kinase, has been shown to have a Src family tyrosine kinase-dependent transphosphorylation...

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Identifiers

PMID: 12081135
DOI: 10.1248/bpb.25.718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site.PMID 12081135Read ↗

Role of the autophosphorylation site on the biological function of pp56lck.Semantic proximity Read ↗

Identification of phosphorylation sites for Bruton's tyrosine kinase within the transcriptional regulator BAP/TFII-I.Semantic proximity Read ↗

Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases.Semantic proximity Read ↗

The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species.Semantic proximity Read ↗

Biochemical and genetic analyses of the Tec kinases Itk and Rlk/Txk.Semantic proximity Read ↗

<i>In Vivo</i>Consequences of Disrupting SH3-Mediated Interactions of the Inducible T-Cell KinaseSemantic proximity Read ↗

The tyrosine kinase Src promotes phosphorylation of the kinase TBK1 to facilitate type I interferon production after viral infection.Semantic proximity Read ↗

DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 binding.Semantic proximity Read ↗

E41K Mutation Activates Bruton’s Tyrosine Kinase by Stabilizing an Inositol Hexakisphosphate dependent Invisible DimerSemantic proximity Read ↗

Positive feedback regulation of PLCgamma1/Ca(2+) signaling by PKCtheta in restimulated T cells via a Tec kinase-dependent pathway.Semantic proximity Read ↗

Negative regulation of Jak2 by its auto-phosphorylation at tyrosine 913 via the Epo signaling pathway.Semantic proximity Read ↗

Protein-tyrosine kinase Pyk2 is involved in interleukin-2 production by Jurkat T cells via its tyrosine 402.Semantic proximity Read ↗

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