Many different papillomaviruses have low transcriptional activity in spite of strong epithelial specific enhancers.

doi:10.1099/0022-1317-80-7-1715

Article

Many different papillomaviruses have low transcriptional activity in spite of strong epithelial specific enhancers.

1 Jul 1999

Abstract excerpt

Transcription of the E6-E7 genes of human papillomavirus type 11 (HPV-11), HPV-16 and HPV-18 is specific to epithelial cells. This mechanism originates from synergism between different transcription factors such as AP-1, NFI and Sp1, which occur in many different cell types, but whose activity is biased in favour of epithelial cells. In this study, the transcriptional regulation of 14 different papillomavirus...

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