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Article

Genetic analysis of modifying loci on mouse chromosome 1 that affect disease severity in a model of recessive PKD.

Physiological genomics - 31 Aug 1999

Iakoubova O, Dushkin H, Pacella L, Beier D R

Abstract excerpt

Using a cross between C57BL/6J and FVB/N mice, we have confirmed the localization on chromosome 1 of a modifying locus that affects the severity of polycystic kidney disease (PKD) in the juvenile cystic kidney (jck) mouse. Despite the highly significant contribution of this locus in F2 progeny of a cross between C57BL/6J and DBA/2J mice (4), a series of congenic strains carrying regions of chromosome 1 on a...

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Source

Identifiers

PMID: 11015567
DOI: 10.1152/physiolgenomics.1999.1.2.101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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