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Article

Cumulative number of cell divisions as a meaningful timescale for adaptive laboratory evolution of Escherichia coli.

PloS one - 1 Jan 2011

Lee Dae-Hee, Feist Adam M, Barrett Christian L, Palsson Bernhard Ø

Abstract excerpt

Adaptive laboratory evolution (ALE) under controlled conditions has become a valuable approach for the study of the genetic and biochemical basis for microbial adaptation under a given selection pressure. Conventionally, the timescale in ALE experiments has been set in terms of number of generations. As mutations are believed to occur primarily during cell division in growing cultures, the cumulative number of...

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PMID: 22028828
DOI: 10.1371/journal.pone.0026172
PMCID: PMC3196513

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