Article
Inactivation of the mouse Huntington's disease gene homolog Hdh.
Science (New York, N.Y.) - 21 Jul 1995
Duyao M P, Auerbach A B, Ryan A, Persichetti F, Barnes G T, McNeil S M, Ge P, Vonsattel J P, Gusella J F, Joyner A L
Abstract excerpt
Huntington's disease (HD) is a dominant neurodegenerative disorder caused by expansion of a CAG repeat in the gene encoding huntingtin, a protein of unknown function. To distinguish between "loss of function" and "gain of function" models of HD, the murine HD homolog Hdh was inactivated by gene targeting. Mice heterozygous for Hdh inactivation were phenotypically normal, whereas homozygosity resulted in embryonic...
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