Article
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase.
Cell - 2 Jun 1995
Tewari M, Quan L T, O'Rourke K, Desnoyers S, Zeng Z, Beidler D R, Poirier G G, Salvesen G S, Dixit V M
Abstract excerpt
Although the mechanism of mammalian apoptosis has not been elucidated, a protease of the CED-3/ICE family is anticipated to be a component of the death machinery. Several lines of evidence predict that this protease cleaves the death substrate poly(ADP-ribose) polymerase (PARP) to a specific 85 k...
Topics
- Apoptosis
- Caenorhabditis elegans Proteins
- Caspase 1
- Caspase 3
- Caspases
- Cloning, Molecular
- Cysteine Endopeptidases
- DNA, Complementary
- Enzyme Activation
- Enzyme Precursors
- Helminth Proteins
- Humans
- Molecular Sequence Data
- Mutagenesis
- Mutation