Article
A novel variant of the catalytic triad in the Streptomyces scabies esterase.
Nature structural biology - 1 Mar 1995
Wei Y, Schottel J L, Derewenda U, Swenson L, Patkar S, Derewenda Z S
Abstract excerpt
The crystal structure of a novel esterase from Streptomyces scabies, a causal agent of the potato scab disease, was solved at 2.1 A resolution. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases. The active site contains a dyad of Ser 14 and His 283, closely resembling two of the three components of typical Ser-His-Asp(Glu)...
Topics
- Amino Acid Sequence
- Antibodies, Catalytic
- Binding Sites
- Esterases
- Genetic Variation
- Hydrogen Bonding
- Models, Molecular
- Molecular Sequence Data
- Protein Structure, Tertiary
- Streptomyces
- Water