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Article

Structure and possible mechanism of the CcbJ methyltransferase from Streptomyces caelestis.

Acta crystallographica. Section D, Biological crystallography - 1 Apr 2014

Bauer Jacob, Ondrovičová Gabriela, Najmanová Lucie, Pevala Vladimír, Kameník Zdeněk, Koštan Július, Janata Jiří, Kutejová Eva

Abstract excerpt

The S-adenosyl-L-methionine (SAM)-dependent methyltransferase CcbJ from Streptomyces caelestis catalyzes one of the final steps in the biosynthesis of the antibiotic celesticetin, methylation of the N atom of its proline moiety, which greatly enhances the activity of the antibiotic. Since several celesticetin variants exist, this enzyme may be able to act on a variety of substrates. The structures of CcbJ...

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PMID: 24699640
DOI: 10.1107/S139900471303397X

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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