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Article

Characterization of a novel Ser-cisSer-Lys catalytic triad in comparison with the classical Ser-His-Asp triad.

The Journal of biological chemistry - 4 Jul 2003

Shin Sejeong, Yun Young Sung, Koo Hyun Min, Kim Yu Sam, Choi Kwan Yong, Oh Byung-Ha

Abstract excerpt

Amidase signature family enzymes, which are widespread in nature, contain a newly identified Ser-cisSer-Lys catalytic triad in which the peptide bond between Ser131 and the preceding residue Gly130 is in a cis configuration. In order to characterize the property of the novel triad, we have determined the structures of five mutant malonamidase E2 enzymes that contain a Cys-cisSer-Lys, Ser-cisAla-Lys, or...

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Identifiers

PMID: 12711609
DOI: 10.1074/jbc.M302156200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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