Article
Harvesting the high-hanging fruit: the structure of the YdeN gene product from Bacillus subtilis at 1.8 angstroms resolution.
Acta crystallographica. Section D, Biological crystallography - 1 Jun 2004
Janda Izabela, Devedjiev Yancho, Cooper David, Chruszcz Maksymilian, Derewenda Urszula, Gabrys Aleksandra, Minor Wladek, Joachimiak Andrzej, Derewenda Zygmunt S
Abstract excerpt
High-throughput (HT) protein crystallography is severely impeded by the relatively low success rate of protein crystallization. Proteins whose structures are not solved in the HT pipeline owing to attrition in any phase of the project are referred to as the high-hanging fruit, in contrast to those proteins that yielded good-quality crystals and crystal structures, which are referred to as low-hanging fruit. It...
Topics
- Amino Acid Motifs
- Amino Acid Sequence
- Bacillus subtilis
- Biophysical Phenomena
- Biophysics
- Crystallography, X-Ray
- Entropy
- Escherichia coli
- Glutamine
- Hydrolases
- Lysine
- Models, Molecular
- Molecular Sequence Data