Development of a Polymerase Chain Reaction/Ligase Detection Reaction Assay for Detection of CYP2C19 Polymorphisms.

doi:10.1089/gtmb.2017.0086

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Article

Development of a Polymerase Chain Reaction/Ligase Detection Reaction Assay for Detection of CYP2C19 Polymorphisms.

Genetic testing and molecular biomarkers - 1 Jan 2018

Zhang Jing, Zhang Hui, Li Kun, Shi Ming

Abstract excerpt

AIMS: Cytochrome P450 2C19 (CYP2C19) genotypes are associated with differential drug metabolism. The aim of this study was to establish a reliable assay for CYP2C19 genotyping based on a polymerase chain reaction/ligase detection reaction (PCR-LDR). MATERIALS AND METHODS: Specific primers and probes were designed to detect CYP2C19*1, *2, *3, and *17. A control for each allele was prepared and used for performance...

Topics

Adult
Aged
Alleles
Cytochrome P-450 CYP2C19
DNA Primers
Female
Gene Frequency
Genotype
Genotyping Techniques
Humans
Ligase Chain Reaction
Male
Middle Aged
Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 29345984
DOI: 10.1089/gtmb.2017.0086

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