Article
Retinal degeneration in mice lacking the gamma subunit of the rod cGMP phosphodiesterase.
Science (New York, N.Y.) - 17 May 1996
Tsang S H, Gouras P, Yamashita C K, Kjeldbye H, Fisher J, Farber D B, Goff S P
Abstract excerpt
The retinal cyclic guanosine 3',5'-monophosphate (cGMP) phosphodiesterase (PDE) is a key regulator of phototransduction in the vertebrate visual system. PDE consists of a catalytic core of alpha and beta subunits associated with two inhibitory gamma subunits. A gene-targeting approach was used to...
Topics
- 3',5'-Cyclic-GMP Phosphodiesterases
- Animals
- Base Sequence
- Chimera
- Crosses, Genetic
- Cyclic GMP
- Electroretinography
- Enzyme Activation
- Female
- Gene Targeting
- Humans
- Light
- Male
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- Mutation
- Phenotype