Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gating of heteromeric retinal rod channels by cyclic AMP: role of the C-terminal and pore domains.

Biophysical journal - 1 Aug 2002

Bennett Nelly, Ildefonse Michèle, Pagès Frédérique, Ragno Michel

Abstract excerpt

Cyclic nucleotide-gated channels are tetramers composed of homologous alpha and beta subunits. C-terminal truncation mutants of the alpha and beta subunits of the retinal rod channel were expressed in Xenopus oocytes, and analyzed for cGMP- and cAMP-induced currents (single-channel records and macroscopic currents). When the alpha subunit truncated downstream of the cGMP-binding site (alpha D608stop) is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cattle
Share to Cyclic AMP
Share to Cyclic GMP

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Drug

Share to Patch-Clamp Techniques

Share to Recombinant Fusion Proteins

Share to Retinal Rod Photoreceptor Cells

Share to Xenopus

Source

Open in PubMed Open full text

Identifiers

PMID: 12124274
DOI: 10.1016/S0006-3495(02)75218-1
PMCID: PMC1302196

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gating of heteromeric retinal rod channels by cyclic AMP: role of the C-terminal and pore domains.PMID 12124274Read ↗

Two alternatively spliced forms of the cGMP-gated channel alpha-subunit from cone photoreceptor are expressed in the chick pineal organ.Semantic proximity Read ↗

A truncated form of rod photoreceptor PDE6 β-subunit causes autosomal dominant congenital stationary night blindness by interfering with the inhibitory activity of the γ-subunit.Semantic proximity Read ↗

Functional consequences of progressive cone dystrophy-associated mutations in the human cone photoreceptor cyclic nucleotide-gated channel CNGA3 subunit.Semantic proximity Read ↗

The glutamic acid-rich protein is a gating inhibitor of cyclic nucleotide-gated channels.Semantic proximity Read ↗

Functional analysis of rod monochromacy-associated missense mutations in the CNGA3 subunit of the cone photoreceptor cGMP-gated channel.Semantic proximity Read ↗

Functional role of hCngb3 in regulation of human cone cng channel: effect of rod monochromacy-associated mutations in hCNGB3 on channel function.Semantic proximity Read ↗

Tyrosine phosphorylation of rod cyclic nucleotide-gated channels switches off Ca2+/calmodulin inhibition.Semantic proximity Read ↗

The carboxyl terminus of the gamma-subunit of rod cGMP phosphodiesterase contains distinct sites of interaction with the enzyme catalytic subunits and the alpha-subunit of transducin.Semantic proximity Read ↗

Functional asymmetry and essential structural roles of PDE6α and PDE6β subunits in rod-photoreceptor integrity.Semantic proximity Read ↗

Retinoids restore normal cyclic nucleotide sensitivity of mutant ion channels associated with cone dystrophy.Semantic proximity Read ↗

An intersubunit interaction regulates trafficking of rod cyclic nucleotide-gated channels and is disrupted in an inherited form of blindness.Semantic proximity Read ↗

Dominant cone and cone-rod dystrophies: functional analysis of mutations in retGC1 and GCAP1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.