Spontaneously occurring staphylococcal mutants resistant to clinically achievable concentrations of ciprofloxacin and temafloxacin.

doi:10.1007/BF02098088

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Article

Spontaneously occurring staphylococcal mutants resistant to clinically achievable concentrations of ciprofloxacin and temafloxacin.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 1 Mar 1992

Barry A L, Pfaller M A, Fuchs P C

Abstract excerpt

The frequency of spontaneously occurring mutants resistant to 0.5, 1, 2, 4 and 8 micrograms of temafloxacin or ciprofloxacin per milliliter was documented with four Staphylococcus aureus and four Staphylococcus epidermidis strains. Resistant mutants were recovered at two- to four-fold the MIC of...

Topics

Anti-Infective Agents
Ciprofloxacin
Drug Resistance, Microbial
Fluoroquinolones
Microbial Sensitivity Tests
Mutation
Quinolones
Staphylococcus aureus
Staphylococcus epidermidis

Source

Open in PubMed

Identifiers

PMID: 1317799
DOI: 10.1007/BF02098088

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1317799-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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