Article
Lack of complete correlation between emetic and T-cell-stimulatory activities of staphylococcal enterotoxins.
Infection and immunity - 1 Aug 1993
Harris T O, Grossman D, Kappler J W, Marrack P, Rich R R, Betley M J
Abstract excerpt
This study examined the emetic activity of several staphylococcal enterotoxin type A and B (SEA and SEB, respectively) mutants that had either one or two amino acid residue substitutions. New sea gene mutations were constructed by site-directed mutagenesis; gene products were obtained with glycine residues at position 25, 47, 48, 81, 85, or 86 of mature SEA. Culture supernatants from Staphylococcus aureus RN4220,...
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