Article
The PKU mouse project: its history, potential and implications.
Acta paediatrica (Oslo, Norway : 1992). Supplement - 1 Dec 1994
McDonald J D
Abstract excerpt
To produce genetic-based animal models for the human disease phenylketonuria (PKU), we treated mice with the powerful germline mutagen ethylnitrosourea and screened the progeny of these animals for the symptom hyperphenylalaninemia (HPH). Six independent mutant strains have been produced to date that exhibit heritable HPH. The first mutation isolated was found to cause a reduced level of GTP-cyclohydrolase I...
Topics
- Animals
- Disease Models, Animal
- Mice
- Mice, Transgenic
- Mutation
- Phenylalanine Hydroxylase
- Phenylketonurias