Mouse models of human phenylketonuria.

doi:10.1093/genetics/134.4.1205

Back to search

Article

Mouse models of human phenylketonuria.

Genetics - 1 Aug 1993

Shedlovsky A, McDonald J D, Symula D, Dove W F

Abstract excerpt

Phenylketonuria (PKU) results from a deficiency in phenylalanine hydroxylase, the enzyme catalyzing the conversion of phenylalanine (PHE) to tyrosine. Although this inborn error of metabolism was among the first in humans to be understood biochemically and genetically, little is known of the mech...

Topics

Animals
Blotting, Western
Cross Reactions
Diet
Disease Models, Animal
Genotype
Humans
Mice
Mutagenesis
Phenylalanine
Phenylalanine Hydroxylase
Phenylketonurias

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.