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Breeding the phenylketonuria mouse: novel dietary regimen enables breeding of female C57BL/6J mice homozygous for the <i> Pah <sup>enu2</sup> </i> mutation without fostering

2022-12-14

Abstract excerpt

The Pah enu2 mutation in C57BL/6J mice is a well characterized model for studying phenylketonuria (PKU), with Pah enu2 homozygotes displaying heightened blood phenylalanine and other characteristics of PKU. Pah enu2 homozygous females do not successfully rear young on any conventional diet due to their disease status. The most commonly used successful breeding strategy is crossing Pah enu2 heterozygous fem...

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Literature Corpus work
60803e08-bf0d-59c1-84c5-7482551cea50
DOI
10.1101/2022.12.12.520145
Open publication

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Breeding the phenylketonuria mouse: novel dietary regimen enables breeding of female C57BL/6J mice homozygous for the <i> Pah <sup>enu2</sup> </i> mutation without fosteringDOI 10.1101/2022.12.12.520145
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