Pahhph-5: a mouse mutant deficient in phenylalanine hydroxylase.

doi:10.1073/pnas.87.5.1965

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Article

Pahhph-5: a mouse mutant deficient in phenylalanine hydroxylase.

Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 1990

McDonald J D, Bode V C, Dove W F, Shedlovsky A

Abstract excerpt

Mutant mice exhibiting heritable hyperphenylalaninemia have been isolated after ethylnitrosourea mutagenesis of the germ line. We describe one mutant pedigree in which phenylalanine hydroxylase activity is severely deficient in homozygotes and reduced in heterozygotes while other biochemical comp...

Topics

Animals
Blotting, Southern
Crosses, Genetic
DNA
Female
Genotype
Heterozygote
Homozygote
Liver
Male
Mice
Mice, Mutant Strains
Mutation
Phenylalanine Hydroxylase
Recombination, Genetic

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