Article
Growth versus function in the three-dimensional culture of single and aggregated hepatocytes within collagen gels.
Biotechnology progress - 1 Jan 2000
Parsons-Wingerter P A, Saltzman W M
Abstract excerpt
Hepatocytes require cell-cell and cell-substrate interactions to survive and function. Furthermore, cell proliferation and differentiated function are often reciprocally related activities, both of which are highly regulated in the liver microenvironment. To mimic the physiological organization of hepatocytes into multicellular plates, small hepatocyte aggregates containing an average of 4-6 cells were formed....
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