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Article

ECM proteins in a microporous scaffold influence hepatocyte morphology, function, and gene expression

29 Nov 2016

Abstract excerpt

It is well known that a three-dimensional (3D) culture environment and the presence of extracellular matrix (ECM) proteins facilitate hepatocyte viability and maintenance of the liver-specific phenotype in vitro. However, it is not clear whether specific ECM components such as collagen or fibronectin differentially regulate such processes, especially in 3D scaffolds. In this study, a series of ECM-functionalized...

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PMID: 27897167
DOI: 10.1038/srep37427

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