Article
The amyloid beta protein precursor mutations linked to familial Alzheimer's disease alter processing in a way that fosters amyloid deposition.
The Tohoku journal of experimental medicine - 1 Nov 1994
Younkin S G
Abstract excerpt
Normal processing of the amyloid beta protein precursor (BAPP) results in secretion of a soluble 4 kD protein essentially identical to the amyloid beta protein (A beta) that forms insoluble fibrillar deposits in Alzheimer's disease (AD). Strong evidence that amyloid deposition plays a critical ro...
Topics
- Aging
- Alzheimer Disease
- Amyloid
- Amyloid Precursor Protein Secretases
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Aspartic Acid Endopeptidases
- Down Syndrome
- Endopeptidases
- Humans
- Models, Neurological
- Nerve Tissue Proteins
- Neuroblastoma
- Peptide Fragments
- Phenotype
- Point Mutation
- Protein Processing, Post-Translational
- Recombinant Proteins